--- title: "Download: Next Generation Materials for Somatic Mutation Detection" description: Next Generation Reference Materials for Somatic Mutation Detection in Circulating Cell-Free DNA image: https://digital.seracare.com/hubfs/Next%20Generation%20Reference%20Materials%20for%20Somatic%20Mutation%20Detection%20in%20Circulating%20Cell-Free%20DNA.png --- ![logo](https://seracare.com/Content/themes/Skin_Default/images/lgc_logo.png) SeraCare is part of LGC Clinical Diagnostics - [Learn More](https://www.lgcclinicaldiagnostics.com/) [![Cart](https://digital.seracare.com/hs-fs/hubfs/raw_assets/public/SeraCare_April2021/images/seracare__cart-icon.png?width=1000&name=seracare__cart-icon.png "Cart")](https://www.seracare.com/shopping-cart/) [![LGC CDx LogoAsset 4-1](https://digital.seracare.com/hs-fs/hubfs/0.%20Logos/CDx/LGC%20CDx%20LogoAsset%204-1.png?width=711&height=268&name=LGC%20CDx%20LogoAsset%204-1.png "LGC CDx LogoAsset 4-1")](https://www.seracare.com/) X ![Search Icon](https://digital.seracare.com/hs-fs/hubfs/raw_assets/public/SeraCare_April2021/images/seracare__search-icon.png?width=1000&name=seracare__search-icon.png "Search Icon") [![SeraCare](https://digital.seracare.com/hs-fs/hubfs/0.%20Logos/SeraCare/SeraCare.jpg?width=400&height=126&name=SeraCare.jpg "SeraCare")](https://www.seracare.com/) - 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These advances lead to a need for patientlike reference materials (RMs) with more clinically relevant alterations at lower levels than before. To address this need, we generated novel circulating tumor DNA (ctDNA) RMs that combine much of the content of our Seraseq™ ctDNA reference materials and add additional variants and copy number alterations (CNAs). Because limits of detection of individual mutations are now at or below 0.2 % variant allele frequency (VAF) in some ctDNA assays, we also reduced the lowest VAF from 0.1 % to 0.01 %. Here we provide data on the initial testing of these RMs. **To download, fill out the form and you will receive an email with the content.** ![Scientific poster: Next Generation Reference Materials for Somatic Mutation Detection in Circulating Cell-Free DNA](https://digital.seracare.com/hs-fs/hubfs/Next%20Generation%20Reference%20Materials%20for%20Somatic%20Mutation%20Detection%20in%20Circulating%20Cell-Free%20DNA.png?width=1412&height=808&name=Next%20Generation%20Reference%20Materials%20for%20Somatic%20Mutation%20Detection%20in%20Circulating%20Cell-Free%20DNA.png "Scientific poster: Next Generation Reference Materials for Somatic Mutation Detection in Circulating Cell-Free DNA") Scroll to top ### Subscribe to One of Our Diagnostic Precision Blogs [![SeraCare](https://digital.seracare.com/hs-fs/hubfs/0.%20Logos/SeraCare/SeraCare.jpg?width=400&height=126&name=SeraCare.jpg "SeraCare")](https://www.seracare.com/) 37 Birch Street Milford, MA 01757 508-244-6400 508-634-3334 Fax ## Products - [NGS & Digital PCR Tools](https://www.seracare.com/Controls---Reference-Materials-NGS/) - [Controls & Reference Materials](https://www.seracare.com/Controls-Reference-Materials/) - [Validation & Qualification Materials](https://www.seracare.com/Validation---Qualification-Materials/) - [Plasma & Serum Diluents & Derivatives](https://www.seracare.com/Plasma---Serum-Diluents---Derivatives/) - [Cell Culture Reagents](https://www.seracare.com/Cell-Culture-Reagents/) - [KPL Antibodies & Conjugates](https://www.seracare.com/KPL-Antibodies---Conjugates/) - [KPL Immunoassay Reagents & Kits](https://www.seracare.com/KPL-Immunoassay-Reagents---Kits/) ## SeraCare - [About Us](https://www.seracare.com/about-seracare/) - [Careers](https://www.seracare.com/about-seracare/careers/) - [Press Releases](https://www.seracare.com/about-seracare/press-releases/) - [News Articles](https://www.seracare.com/about-seracare/news-articles/) - [Quality Systems](https://www.seracare.com/about-seracare/quality-systems/) - [Terms & Conditions](https://www.seracare.com/terms-conditions/) - [Privacy Policy & Legal Statement](https://www.seracare.com/privacy-policy/) ## Support & Resources - [Register for an Account](https://www.seracare.com/sign-in/) - [Contact Us](https://www.seracare.com/contact-us/) - [Sign In](https://www.seracare.com/sign-in/) - [Resource Library](https://www.seracare.com/resourcelibrary/) - [FAQs](https://www.seracare.com/resources-and-education/faqs/) - [Scientific Posters](https://www.seracare.com/resources-and-education/scientific-posters/) - [White Papers](https://www.seracare.com/resources-and-education/white-papers/) - [Videos](https://www.seracare.com/resources-and-education/videos/)