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title: Download this Scientific Poster
description: The BRCA 1 and BRCA 2 tumor suppressors genes limit DNA damage, consequently, loss of function mutations in these genes lead to increased incidence of breast, ovarian, and prostate cancer.
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# Multi-site evaluation of novel BRCA1/2 reference materials including large genomic rearrangements

The BRCA 1 and BRCA 2 tumor suppressors genes limit DNA  
damage, consequently, loss of function mutations in these genes  
lead to increased incidence of breast, ovarian, and prostate cancer.  
Accurate detection of BRCA variants is thus of paramount  
importance for patients with somatic cancer to guide treatment  
strategies, such as eligibility for PARP inhibitor therapy, and for  
individuals carrying inherited mutations to consider preventive  
actions

Download this scientific poster to learn how newly developed reference materials to support both BRCA1 and BRCA2 inherited and somatic genetic testing, can provide your laboratories and assay developers with tools to challenge and optimize their assay’s detection and quantitation of pathogenic variants by NGS. 

 

**To download, fill out the form and you will receive an email with the content.**

![AACR 2023 SP - Multi site evaluation of novel BRCA12 reference materials including genomic rearragements](https://digital.seracare.com/hs-fs/hubfs/AACR%202023%20SP%20-%20Multi%20site%20evaluation%20of%20novel%20BRCA12%20reference%20materials%20including%20genomic%20rearragements.jpg?width=350&height=197&name=AACR%202023%20SP%20-%20Multi%20site%20evaluation%20of%20novel%20BRCA12%20reference%20materials%20including%20genomic%20rearragements.jpg "AACR 2023 SP - Multi site evaluation of novel BRCA12 reference materials including genomic rearragements")

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