FEATURES 

• Develop, monitor, validate, and challenge your BRCA NGS assays with confidence using a highly multiplexed reference material containing biomarkers important in BRCA-driven cancers. 

• 20 pathogenic BRCA1/2 variants (11 LGRs, 9 deletions, 5 SNVs, 4 indels, and 2 insertions).
  
  
• Available as full process (FFPE curl) or purified genomic DNA at various allele frequencies suited for either somatic or germline testing.
  
  
• Mutation targets quantitated by highly sensitive dPCR assays, and orthogonally analyzed by NGS.
  
  
• All mutations are blended against the well-characterized GM24385 human genomic DNA as ‘wildtype’ background material. 

Scientific Poster 
Reference Materials for Analysis of BRCA1 and BRCA2 Gene Variants with Expansion to Large Genomic Rearrangements (LGRs) to Support Therapy Selection in Breast and Ovarian Cancer Patients
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Product Sheet 
Seraseq BRCA1/2 LGR Products 
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