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Unlike other hematological malignancies that are characterized by a defined genetic abnormality – such as the BCR::ABL1 translocation in chronic myelogenous leukemia – AML is associated with numerous different mutations that vary between patients. While about a third of AML patients harbor a mutation in NPM1 and/or an internal tandem duplication (ITD) in FLT3, this is not the case for the majority of patients. This complicates the monitoring of the presence or absence of MRD during and after treatment because assays need to be very sensitive but inexpensive enough to allow for repeated measurements over time. For example, in the absence of an NPM1 or FLT3-ITD mutation, it may be beneficial to design patient-specific assays that focus on only the mutations found in that patient’s AML. 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